Terapija Intrakoštanog Defekta S Humanim Trombocitnim Čimbenikom Rasta I Beta Trikalcijevim Fosfatom

s of Croatian Periodontology Days 2011 congress Zagreb, Croatia, May 6-7, 2011 Urednik • Editor: Ivan Puhar Predsjednik • President: Darije Plančak POSTER PRESENTATIONS THERAPY OF INTRABONY DEFECT WITH HUMAN PLATELET GROWTH FACTOR AND BETA-TRICALCIUM PHOSPHATE Darko Božić, Domagoj Vražić, Ana Badovinac, Ivan Puhar, Darije Plančak Department of Periodontology, School of Dental Medicine, University of Zagreb A variety of bone grafts, grafting materials and proteins are used today in order to achieve the regeneration of tissues around the teeth. These materials can sometimes be covered with membrane to allow necessary time for bone to regenerate. The success is associated with the extent and morphology of bone defect, but also with the level of oral hygiene which is why it is sometimes difficult to predict the final result. The initial therapy was performed at patient referred to the Department of Periodontology, School of Dental Medicine, University of Zagreb. Six months after the initial therapy and regular supportive therapy once a month, we measured an inactive pocket on tooth 11 mesially and palatally that was 9 mm deep. We decided to perform regenerative surgery using recombinant human platelet growth factor (rhPDGF-BB) and beta tricalcium phosphate (β-TCP). After raising a full thickness flap we observed a two and one wall infrabony defect mesially and a circumferential defect palatally. After removing all the granulation tissue and root planing, a regenerative material GEM 21S®, which consists of rhPDGF-BB and β-TCP was mixed in a Petri dish. Saturated osteoconductive matrix with bioactive protein was ready for use after 10 min. With moderate pressure the material was placed in infrabony defect up to the level of bone crest taking care not to overfill. Very fast healing of soft tissue and primary wound healing was observed at the first checkup two weeks after. Probing pocket depth mesially was 4mm six months after. A newly formed bone on the mesial of tooth 11 was radiologically visible. The successful initial therapy supplemented with corrective regenerative procedure on a tooth 11 resulted in 5 mm of attachment gain.